PDB Entry - 6EEO

(Status - Released)

Summary information:

Title: Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines.

PDB DOI: https://doi.org/10.2210/pdb6eeo/pdb

Primary publication DOI: https://doi.org/10.1021/acs.jmedchem.8b01504

Entry authors: Singh, S., McKenna, R., Supuran, C.T., Nocentini, A., Lomelino, C., Lucarini, E., Bartolucci, G., Mannelli, L.D.C., Ghelardini, C., Gratteri, P.

Initial deposition on: 15 August 2018

Initial release on: 28 November 2018

Latest revision on: 11 October 2023

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Structure coordinates (PDBML)

Structure coordinates (PDB)

X-ray diffraction data (PDBx/mmCIF)

Validation report (XML)

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Validation report (mmCIF)

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