PDB Entry - 5AAU
(Status - Released)Summary information:
Title: Optimization of a novel binding motif to to (E)-3-(3,5-difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H- pyrido(3,4-b)indol-1-yl)phenyl)acrylic acid (AZD9496), a potent and orally bioavailable selective estrogen receptor downregulator and antagonist
PDB DOI: https://doi.org/10.2210/pdb5aau/pdb
Primary publication DOI: https://doi.org/10.1021/ACS.JMEDCHEM.5B00984
Entry authors: Norman, R.A., Bradbury, R.H., de Almeida, C., Andrews, D.M., Ballard, P., Buttar, D., Callis, R.J., Currie, G.S., Curwen, J.O., Davies, C.D., de Savi, C., Donald, C.S., Feron, L.J.L., Glossop, S.C., Hayter, B.R., Karoutchi, G., Lamont, S.G., MacFaul, P., Moss, T., Pearson, S.E., Rabow, A.A., Tonge, M., Walker, G.E., Weir, H.M., Wilson, Z.
Initial deposition on: 28 July 2015
Initial release on: 14 October 2015
Latest revision on: 1 May 2024
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Structure coordinates (PDB)
X-ray diffraction data (PDBx/mmCIF)
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Validation report (mmCIF)
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